Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway

Obesity and hyperlipidemia are major risk factors for developing vascular diseases. Bee bread (BB) has been reported to exhibit some biological actions, including anti-obesity and anti-hyperlipidemic. This study aims to investigate whether bee bread can ameliorate vascular inflammation and impaired vasorelaxation activity through eNOS/NO/cGMP pathway in obese rats. Forty male Sprague-Dawley rats were randomly divided into four groups (n = 10/group), namely: control (normal group), obese rats (OB group), obese rats treated with bee bread (0.5 g/kg/day, OB/BB group) and obese rats treated with orlistat (10 mg/kg/day, OB/OR group). The latter three groups were given a high-fat diet (HFD) for 6 weeks to induced obesity before being administered with their respective treatments for another 6 weeks. After 12 weeks of the total experimental period, rats in the OB group demonstrated significantly higher Lee obesity index, lipid profile (total cholesterol, triglyceride, low-density lipoprotein), aortic proinflammatory markers (tumor necrosis factor-α, nuclear factor-κβ), aortic structural damage and impairment in vasorelaxation response to acetylcholine (ACh). Bee bread significantly ameliorated the obesity-induced vascular damage manifested by improvements in the lipid profile, aortic inflammatory markers, and the impaired vasorelaxation activity by significantly enhancing nitric oxide release, promoting endothelial nitric oxide synthase (eNOS) and cyclic guanosine monophosphate (cGMP) immunoexpression. These findings suggest that the administration of bee bread ameliorates the impaired vasorelaxation response to ACh by improving eNOS/NO/cGMP-signaling pathway in obese rats, suggesting its vascular therapeutic role.     

Perception of Artificial Intelligence in Spain

This paper analyses the perception of Artificial Intelligence (AI) by individuals in Spain and the factors associated with it. It uses data from 6308 individuals from a 2018 Spanish survey. A binary logit regression model is formulated and estimated for the attitude towards robots and AI and its possible determinants. As main results are that a gender gap is detected, and that people have a negative attitude if they are not interested in scientific discoveries and technological developments and if AI and robots are not useful at work.     

Application of artificial neural network method to predict the breakage properties of PGE bearing chromite ore

In the present investigation, systematic grinding experiments were conducted in a laboratory ball mill to determine the breakage properties of low-grade PGE bearing chromite ore. The population balance modeling technique was used to study the breakage parameters such as primary breakage distribution (B_{i, j}) and the specific rates of breakage (S_i). The breakage and selection function values were determined for six feed sizes. The results stated that the breakage follows the first-order grinding kinetics for all the feed sizes. It was observed that the coarser feed sizes exhibit higher selection function values than the finer feed size. Further, an artificial neural network was used to predict breakage characteristics of low-grade PGE bearing chromite ore. The predicted results obtained from the neural network modeling were close to the experimental results with a correlation of determination R² = 0.99 for both product size and selection function.     

Local scour at offshore windfarm monopile foundations: A review

In this article, current research findings of local scour at offshore windfarm monopile foundations are presented. The scour mechanisms and scour depth prediction formulas under different hydrodynamic conditions are summarized, including the current-only condition, wave-only condition, combined wave-current condition, and complex dynamic condition. Furthermore, this article analyzes the influencing factors on the basis of classical equations for predicting the equilibrium scour depth under specific conditions. The weakness of existing researches and future prospects are also discussed. It is suggested that future research shall focus on physical experiments under unsteady tidal currents or other complex loadings. The computational fluid dynamics-discrete element method and artificial intelligence technique are suggested being adopted to study the scour at offshore windfarm foundations.     

Zinc doped Fe2O3 for boosting Electrocatalytic Nitrogen Fixation to ammonia under mild conditions

Artificial nitrogen fixation is emerging as a promising approach for synthesis of ammonia at mild conditions. Inspired by biological nitrogen fixation based on bacteria containing iron, zinc doped Fe₂O₃ nanoparticles are proposed as an efficient and earth abundant electrocatalyst for converting N₂ to NH₃. In neutral media, it achieves a maximum Faradaic efficiency (FE) of 10.4% and a large NH₃ yield rate of 15.1 μg h^?1 mg^?1_cat. at ?0.5 V vs. reversible hydrogen electrode. This catalyst also exhibits excellent selectivity and stability. Theoretical calculations suggest the reaction follows the associative enzymatic mechanism and it has a barrier of as low as 0.68 eV.     

An improved method for the hot strip mill production scheduling problem

In most research on the hot strip mill production scheduling problem (HSMPSP) arising in the steel industry, it is accepted that a schedule with lower penalty caused by jumps of width, hardness, and gauge will result in lower roller wear, so it is regarded as a better schedule. However, based on the analysis of production processes, it is realised that rolling each coil also cause roller wear. In order to assessing the roller wear associated with production scheduling more precisely, it is necessary to consider it as another factor besides those jumps, especially when complicated constraints are involved. In this paper, an improved method is proposed to quantify the expected wear of the rollers done by those jumps and rolling processes. Then the HSMPSP whose objective is to maximise the total length of all scheduled coils is formulated as a team orienteering problem with time windows and additional production constraints. A heuristic method combining an improved Ant Colony Extended algorithm with local search procedures dedicated to HSMPSP is developed. Finally, computational results on instances generated based on production data from an integrated steel mill in China indicate that the proposed algorithm is a promising solution specific to HSMPSP.     

基于改进人工蜂群算法的多目标绿色柔性作业车间调度研究

针对多目标绿色柔性作业车间调度问题（MGFJSP）的特点，提出从碳排放量、噪声和废弃物这3个指标来综合评定环境污染程度，建立了以最小化最大完成时间和环境污染程度为优化目标的MGFJSP模型，并提出了一种改进的人工蜂群算法来求解该模型。算法的具体改进包括：设计了一种三维向量的编码和对应解码方案，在跟随蜂搜索阶段引入一种有效的动态邻域搜索操作来提高算法的局部搜索能力，在侦查蜂阶段提出产生新食物源的策略用于增加种群的多样性。最后进行了实验研究与算法对比，以验证所建模型和所提算法的有效性。     

Identification of digital technologies and digitalisation trends in the mining industry

Digitalisation in mining refers to the use of computerised or digital devices or systems and digitised data that are to reduce costs, improve business productivity, and transform mining practices. However, it remains increasingly difficult for mining companies to decide which digital technologies are most relevant to their needs and individual mines. This paper provides an overview of digital technologies currently relevant to mining companies as presented and discussed by mining journals, the media and insight reports of leading consultancy agencies. Relevant technologies were systematically identified using text-mining techniques, and network analyses established the relations between significant technologies. Results demonstrated that currently 107 different digital technologies are pursued in the mining sector. Also, an analysis of the actual implementation of digital technologies in 158 active surface and underground mines reveals a limited uptake of digital technologies in general and that the uptake increases with the run-of-mine production. Large-scale mining operations appear to select and apply digital technologies suitable to their needs, whereas operations with lower production rates do not implement the currently available digital technologies to the same extent. These minor producers may require other digital transformation solutions tailored to their capabilities and needs and applicable to their scale of operations.     

A datamining approach to classify,select and predict the formation enthalpy for intermetallic compound hydrides

In this paper, two techniques of datamining tools were adopted, a principal component analysis (PCA) and artificial neural network (ANN). A PCA to classify, select and identify several combinations between transition element A and B (B = Ti, Zr, Hf, Sc, Y, La and Th) and ANN to predict ΔH for ternary hydrides. Based on the datasets selected from different works, a principal component analysis (PCA) has been applied to select, classify and identify around 76 possible combinations between transition metal elements A and B. The results showed that the clustering of combinations A-B are significantly influenced by the atomic parameters of element A, such atomic radius (R_A), Pauling's electronegativity (χ_A) and atomic electron density (Z_A/R_A³). From 76 combinations, 55 systems which have χ_A ≥ 1.5, Z_A/R_A³>1.28 and R_A < 1.46 Å are categorized as group 1. On the other hand, 21 systems which have χ_A < 1.5, Z_A/R_A³ < 1.28, and R_A > 1.46 Å are categorized as group 2. From the first group, 46 different combinations are identified and have a negative ΔH, within 18 well-known promising binary alloys of hydrogen storage.An (6-15-1) architecture of artificial neural network (ANN) has been developed to estimate the ΔH for the other ternary hydrides selected from different published works. The performance indices such as relative error, coefficient of determination (R²) and mean square error (MSE) were used to control the performance of obtained results. In addition to this, the ΔH obtained from ANN model were compared with those experimental data and theoretical results available in the literature.